Source Paper
Impaired Recognition Memory in Monkeys after Damage Limited to the Hippocampal Region
Stuart M. Zola, Larry R. Squire, Edmond Teng, Lisa Stefanacci, Elizabeth A. Buffalo et al.
Journal of Neuroscience • 2000
View Abstract
Monkeys with lesions limited to the hippocampal region (the hippocampus proper, the dentate gyrus, and the subiculum) were impaired on two tasks of recognition memory: delayed nonmatching to sample and the visual paired-comparison task. Recognition memory was impaired in five different groups of monkeys, whether the lesions were made by an ischemic procedure, by radio frequency, or by ibotenic acid. The finding that the hippocampal region is essential for normal recognition memory performance is considered in the context of current ideas about the role of the hippocampus in declarative memory.
Delayed Nonmatching to Sample
Objective: To assess recognition memory in monkeys by testing their ability to identify a novel object that does not match a previously presented sample after a delay period
Protocol Steps
Present sample object
A sample object is presented to the monkey
Note: This is the initial stimulus that the monkey must remember
View evidence from paper
“delayed nonmatching to sample task in which monkeys must identify a novel object that does not match a previously presented sample”
Implement delay period
A delay interval is imposed between presentation of the sample and the choice phase
Note: The delay period tests the monkey's memory retention
View evidence from paper
“delayed nonmatching to sample and the visual paired-comparison task”
Present choice objects
Two objects are presented: the original sample object and a novel object
Note: The monkey must select the novel object that does not match the sample
View evidence from paper
“monkeys must identify a novel object that does not match a previously presented sample”
Record monkey response
The monkey's choice is recorded to determine if it correctly identified the non-matching novel object
Note: Performance accuracy is the primary outcome measure
View evidence from paper
“Monkeys with lesions limited to the hippocampal region were impaired on two tasks of recognition memory”