Delayed Nonmatching to Sample
Objective: To assess recognition memory in monkeys by testing their ability to identify a novel object that does not match a previously presented sample after a delay period
This is a Delayed Nonmatching to Sample protocol using monkey as the model organism. The procedure involves 4 procedural steps. Extracted from a 2000 paper published in Journal of Neuroscience.
Model and subjects
monkey • not specified • unknown • not specified • not specified
Study window
Estimated timing pending
Core workflow
Present sample object • Implement delay period • Present choice objects
Primary readouts
- Recognition memory performance accuracy
- Ability to identify novel objects that do not match previously presented samples
- Comparison of performance between lesioned and control monkeys
Key equipment and reagents
Verified items
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Direct vendor links
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Protocol Steps
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Present sample object
A sample object is presented to the monkey
Note: This is the initial stimulus that the monkey must remember
View evidence from paper
“delayed nonmatching to sample task in which monkeys must identify a novel object that does not match a previously presented sample”
Implement delay period
A delay interval is imposed between presentation of the sample and the choice phase
Note: The delay period tests the monkey's memory retention
View evidence from paper
“delayed nonmatching to sample and the visual paired-comparison task”
Present choice objects
Two objects are presented: the original sample object and a novel object
Note: The monkey must select the novel object that does not match the sample
View evidence from paper
“monkeys must identify a novel object that does not match a previously presented sample”
Record monkey response
The monkey's choice is recorded to determine if it correctly identified the non-matching novel object
Note: Performance accuracy is the primary outcome measure
View evidence from paper
“Monkeys with lesions limited to the hippocampal region were impaired on two tasks of recognition memory”