Source Paper
Role of glymphatic system function in cognitive dysfunction among patients with bipolar disorder
Chen MH, Liou YJ, Hsu JW, Tsai SJ, Chang CC et al.
Int J Neuropsychopharmacol • 2026
Digit Symbol Substitution Test (DSST)
behavioralHumanNot applicable
Objective: Assessment of cognitive function, specifically processing speed, working memory, and attention using the Digit Symbol Substitution Test
Protocol Steps
1
Task instruction
Participants are instructed to quickly and accurately fill in corresponding symbols for each digit using the provided key table
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“participants are instructed to quickly and accurately fill in the corresponding symbol for each digit using the key table”
2
Symbol-digit matching
Participants match symbols to digits based on a reference key
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“They match symbols to digits based on a reference key”
3
Time limit
Test is completed within a 120-second time limit
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“within 120 seconds”