Discrimination Reversal Task
Objective: Evaluate the effects of basal forebrain cholinergic system lesions on discrimination reversal learning abilities in monkeys
This is a Discrimination Reversal Task protocol using monkey as the model organism. The procedure involves 3 procedural steps, 2 materials. Extracted from a 1994 paper published in Journal of Neuroscience.
Model and subjects
monkey • cynomolgus • Not specified • Not specified • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Discrimination Reversal Task Administration • Lesion Creation • Scopolamine Sensitivity Testing
Primary readouts
- Accuracy in discrimination reversal tasks
- Accuracy in delayed nonmatching-to-sample tasks
- Accuracy in delayed response tasks
- Accuracy in simple visual discriminations
Key equipment and reagents
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Protocol Steps
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Discrimination Reversal Task Administration
Monkeys were tested on discrimination reversal tasks to assess their ability to reverse learned discriminations
Note: This task was part of a large series of cognitive tasks examining different mnemonic and attentional abilities
View evidence from paper
“using a large series of cognitive tasks that examined different mnemonic and attentional abilities”
Lesion Creation
Ibotenic acid injections were administered to the medial septum, nucleus of the diagonal band of Broca, and nucleus basalis of Meynert
Note: Lesions were created in the basal forebrain cholinergic system
View evidence from paper
“ibotenic acid injections in the medial septum, nucleus of the diagonal band of Broca, and nucleus basalis of Meynert in cynomolgus monkeys”
Scopolamine Sensitivity Testing
Monkeys with basal forebrain lesions were tested with scopolamine injections in a delayed nonmatching-to-sample task to assess cholinergic system compromise
Note: This test indicated whether the central cholinergic system was compromised
View evidence from paper
“BFCS lesions increased sensitivity to injections of the cholinergic antagonist scopolamine in a delayed nonmatching-to-sample task”