Source Paper
Dissociable Forms of Inhibitory Control within Prefrontal Cortex with an Analog of the Wisconsin Card Sort Test: Restriction to Novel Situations and Independence from “On-Line” Processing
R. Dias, T. W. Robbins, A. C. Roberts
Journal of Neuroscience • 1997
Discrimination Reversal Task
Objective: Measure the ability to reverse stimulus-reward associations within a perceptual dimension, sensitive to orbitofrontal cortex damage
This is a Discrimination Reversal Task protocol using marmoset as the model organism. The procedure involves 3 procedural steps. Extracted from a 1997 paper published in Journal of Neuroscience.
Model and subjects
marmoset
Study window
Estimated timing pending
Core workflow
Discrimination Reversal Task Setup • Initial Stimulus-Reward Association Learning • Reversal Phase
Primary readouts
- Ability to reverse stimulus-reward associations
- Number of errors during reversal learning
- Speed of reversal learning
- Inhibitory control in affective processing
Key equipment and reagents
Verified items
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Direct vendor links
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Protocol Steps
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Discrimination Reversal Task Setup
Establish a discrimination reversal task to measure the ability to reverse stimulus-reward associations within a particular perceptual dimension
Note: This task is sensitive to orbitofrontal cortex damage and measures inhibitory control in affective processing
View evidence from paper
“orbital but not lateral prefrontal cortex is the critical locus in reversing a stimulus–reward association within a particular perceptual dimension”
Initial Stimulus-Reward Association Learning
Train subjects to learn an initial stimulus-reward association within a perceptual dimension
Note: Establishes the baseline response set that must later be reversed
View evidence from paper
“those prefrontal areas involved in the suppression of previously established response sets are not involved in the acquisition of such response sets”
Reversal Phase
Reverse the stimulus-reward contingencies so that the previously rewarded stimulus is now unrewarded and vice versa
Note: Measures the ability to inhibit the previously learned response set and acquire the new association
View evidence from paper
“discrimination reversal are sensitive to prefrontal damage in the marmoset in a manner qualitatively similar to that seen in man and Old World monkeys”