Source Paper
Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V <sub>1b</sub> receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders
Guy Griebel, Jacques Simiand, Claudine Serradeil-Le Gal, Jean Wagnon, Marc Pascal et al.
Proceedings of the National Academy of Sciences • 2002
Fear/Anxiety Defense Test Battery
Objective: An atypical anxiety model involving traumatic stress exposure to measure fear and defense-related behaviors in response to vasopressin V1b receptor antagonist treatment
This is a Fear/Anxiety Defense Test Battery protocol using rodent (rats and mice) as the model organism. The procedure involves 3 procedural steps, 5 equipment items, 2 materials. Extracted from a 2002 paper published in Proceedings of the National Academy of Sciences.
Model and subjects
rodent (rats and mice) • Not specified • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Fear/Anxiety Defense Test Battery Administration • SSR149415 Administration • Behavioral Observation
Primary readouts
- Fear-related behaviors
- Defense-related behaviors
- Anxiolytic-like activity
- Response to traumatic stress exposure
Key equipment and reagents
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
Confirm first
- Verify the animal model, intervention setup, and collection timepoints against the source paper.
- Check that every direct vendor link matches the exact specification your lab plans to run.
Use the page like this
- Work through the protocol steps in order and use the inline vendor chips only when you need to source or verify an item.
- Jump to Experimental Context for readouts, data shape, and analysis flow before planning downstream analysis.
Protocol Steps
Start here. The step list is optimized for running the experiment, with direct vendor links available inline when you need to source a cited item.
Fear/Anxiety Defense Test Battery Administration
Conduct fear/anxiety defense test battery as an atypical anxiety model involving traumatic stress exposure
Note: This is an atypical model involving traumatic stress exposure designed to measure fear and defense-related behaviors
View evidence from paper
“atypical (fear/anxiety defense test battery and social defeat-induced anxiety) rodent models of anxiety”
SSR149415 Administration
Administer SSR149415 at doses of 1-30 mg/kg via oral (p.o.) route
Note: Oral administration route used for defense test battery testing
View evidence from paper
“SSR149415 produced clear-cut anxiolytic-like activity in models involving traumatic stress exposure, such as the social defeat paradigm and the defense test battery (1–30 mg/kg, p.o.)”
Behavioral Observation
Observe and measure fear and defense-related behaviors during the test battery
Note: Specific behavioral measures not detailed in provided text
View evidence from paper
“fear/anxiety defense test battery and social defeat-induced anxiety”