GO/NO-GO Avoidance Conditioning Task
Objective: Examine the role of auditory cortex in differential conditioning to pure tones and frequency-modulated tones by analyzing effects of bilateral auditory cortex ablation on GO/NO-GO avoidance conditioning performance
Gather these items before starting the experiment. Check off items as you prepare.
1 item available from ConductScience
Estimated: $6,900.00
As an Amazon Associate, we earn from qualifying purchases. Product links help support this free resource.
Protocol Steps
Baseline behavioral assessment
Monitor hurdle crossing as the conditioned response to the reinforced stimulus (CR+), false alarm in response to the unreinforced stimulus (CR−), intertrial activity, and reaction times
Note: Measurements include CR+ rate, CR− rate, intertrial activity, and reaction times
View evidence from paper
“Hurdle crossing as the conditioned response to the reinforced stimulus (CR+), as false alarm in response to the unreinforced stimulus (CR−), intertrial activity, and reaction times were monitored.”
Differential conditioning to pure tones
Train animals to discriminate between pure tones using GO/NO-GO avoidance conditioning in the two-way shuttle box
Note: Pure tone discrimination serves as one experimental condition
View evidence from paper
“This study examines the role of auditory cortex in the Mongolian gerbil in differential conditioning to pure tones and to linearly frequency-modulated (FM) tones”
Differential conditioning to frequency-modulated tones
Train animals to discriminate between linearly frequency-modulated (FM) tones using GO/NO-GO avoidance conditioning in the two-way shuttle box
Note: FM tone discrimination serves as the second experimental condition
View evidence from paper
“This study examines the role of auditory cortex in the Mongolian gerbil in differential conditioning to pure tones and to linearly frequency-modulated (FM) tones”
Bilateral auditory cortex ablation
Perform bilateral ablation of auditory cortex in experimental animals
Note: Lesion timing relative to training is a critical variable - lesions performed either before training in naive animals or in pretrained animals
View evidence from paper
“by analyzing the effects of bilateral auditory cortex ablation”
Post-lesion behavioral assessment in naive animals
Monitor behavioral performance following lesion in animals that have not yet received discrimination training
Note: Lesions before training in naive animals led to a reduced CR+ rate and had no effect on CR− rate
View evidence from paper
“Lesions before training in naive animals led to a reduced CR+ rate and had no effect on CR− rate.”
Post-lesion behavioral assessment in pretrained animals
Monitor behavioral performance following lesion in animals that have already completed discrimination training
Note: Lesions in pretrained animals led to an increased CR− rate without effects on the CR+ rate
View evidence from paper
“Lesions in pretrained animals led to an increased CR− rate without effects on the CR+ rate.”