Source Paper
Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation
Li Z, Quan H, Liu W, Chen J, Chu M et al.
Adv Sci (Weinh) • 2025
Patient Health Questionnaire-9 (PHQ-9)
behavioralHumanNot applicable
Objective: To assess anxiety and depression levels in psoriasis patients and healthy controls using the Patient Health Questionnaire-9 (PHQ-9)
Materials & Equipment Checklist
1 item
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Materials1
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Protocol Steps
1
Subject recruitment and grouping
Recruit psoriasis patients (n=211) and healthy controls (n=239)
View evidence from paper
“psoriasis patients ( n = 211) and healthy controls ( n = 239)”
2
PHQ-9 assessment administration
Conduct Patient Health Questionnaire-9 assessments on all subjects
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“we conducted Patient Health Questionnaire‐9 (PHQ‐9) assessments”
3
Stress level categorization
Divide psoriasis patients into high-stress (PHQ-9 ≥ 7) and low-stress (PHQ-9 < 7) groups
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“psoriasis patients were divided into a high‐stress group (PHQ‐9 ≥ 7) and a low‐stress group (PHQ‐9 < 7)”
4
Compare stress scores between groups
Compare PHQ-9 scores between psoriasis patients and healthy controls
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“Compared to healthy controls (PHQ‐9 mean ± SD: 3.7 ± 3.4), psoriasis patients reported an increased stress perception (PHQ‐9 mean ± SD: 7.8 ± 5.0”
5
Correlation analysis with disease severity
Analyze correlation between PHQ-9 scores and PASI scores
View evidence from paper
“there was a positive correlation between psoriasis severity (PASI) and PHQ‐9 scores ( R = 0.4655, P < 0.01”