Source Paper
Bilateral Orbital Prefrontal Cortex Lesions in Rhesus Monkeys Disrupt Choices Guided by Both Reward Value and Reward Contingency
Alicia Izquierdo, Robin K. Suda, Elisabeth A. Murray
Journal of Neuroscience • 2004
Selective Satiation Test
Objective: Evaluate monkeys' food choices after selective satiation to assess whether satiety mechanisms and the ability to assign value to familiar foods are intact, particularly in comparison between lesioned and control animals
This is a Selective Satiation Test protocol using rhesus monkey as the model organism. The procedure involves 3 procedural steps, 1 materials. Extracted from a 2004 paper published in Journal of Neuroscience.
Model and subjects
rhesus monkey • 10
Study window
Estimated timing pending
Core workflow
Food Preference Test • Selective Satiation • Measure Food Choice Response
Primary readouts
- Food choice preferences after selective satiation
- Ability to reduce selection of satiated food
- Comparison of satiety mechanisms between lesioned and control monkeys
Key equipment and reagents
Verified items
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Direct vendor links
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Protocol Steps
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Food Preference Test
Monkeys are allowed to choose foods alone from six different food options to establish baseline preferences
Note: This test establishes that monkeys can assign value to familiar foods under normal conditions
View evidence from paper
“responded like controls when allowed to choose foods alone, either on a food preference test among six different foods”
Selective Satiation
One of the six foods is selectively presented to satiate the monkey on that specific food item, then the monkey is tested on food choice preferences
Note: Tests whether satiety mechanisms are intact by observing if monkeys reduce choice of the satiated food
View evidence from paper
“or after selective satiation. Thus, satiety mechanisms and the ability to assign value to familiar foods appear to be intact”
Measure Food Choice Response
Observe and record which foods the monkey chooses after selective satiation with one food type
Note: Comparison made between lesioned monkeys and unoperated controls
View evidence from paper
“responded like controls when allowed to choose foods alone, either on a food preference test among six different foods or after selective satiation”