Source Paper
Functional assessments in the rodent stroke model
Krystal L Schaar, Miranda M Brenneman, Sean I Savitz
Experimental & Translational Stroke Medicine • 2010
View Abstract
Abstract Stroke is a common cause of permanent disability accompanied by devastating impairments for which there is a pressing need for effective treatment. Motor, sensory and cognitive deficits are common following stroke, yet treatment is limited. Along with histological measures, functional outcome in animal models has provided valuable insight to the biological basis and potential rehabilitation efforts of experimental stroke. Developing and using tests that have the ability to identify behavioral deficits is essential to expanding the development of translational therapies. The present aim of this paper is to review many of the current behavioral tests that assess functional outcome after stoke in rodent models. While there is no perfect test, there are many assessments that are sensitive to detecting the array of impairments, from global to modality specific, after stroke.
Accelerated Rotarod Test
Objective: Assess motor coordination and balance in rodents
This is a Accelerated Rotarod Test protocol using Not specified in text as the model organism. The procedure involves 2 procedural steps, 1 equipment items. Extracted from a 2010 paper published in Experimental & Translational Stroke Medicine.
Model and subjects
Not specified in text • Not specified in text • unknown • Not specified in text • Not specified in text
Study window
~4 day study window | ~10 minutes hands-on
Core workflow
Training Phase • Testing Phase
Primary readouts
- Motor coordination
- Balance
- Time on rotating rod
- Performance across trials
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Training Phase
Animals undergo training on the accelerated rotarod apparatus
Note: Pre-training is required before testing
View evidence from paper
“Accelerated Rotarod 2-4 days 3 trials 10 minutes”
Testing Phase
Animals are tested on the accelerated rotarod with multiple trials
Note: Three trials are conducted per testing session
View evidence from paper
“Accelerated Rotarod 2-4 days 3 trials 10 minutes”