Source Paper
Synthesis and Structure-Affinity Relationships of Receptor Ligands with 1,3-Dioxane Structure
Quick E, Schepmann D, Wünsch B
Pharmaceuticals (Basel) • 2025
Capsaicin Mouse Model of Neuropathic Pain
Objective: To test analgesic activity of sigma-1 receptor ligands in a capsaicin-induced neuropathic pain model
This is a Capsaicin Mouse Model of Neuropathic Pain protocol using Not specified as the model organism. The procedure involves 3 procedural steps, 2 materials. Extracted from a 2025 paper published in Pharmaceuticals (Basel).
Model and subjects
mouse • not specified • not specified • not specified • not specified • not specified
Study window
Estimated timing pending
Core workflow
Capsaicin Administration • Test Compound Administration • Analgesic Activity Assessment
Primary readouts
- Analgesic activity percentage
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Capsaicin Administration
Administer capsaicin to induce neuropathic pain in mice
Note: This creates the neuropathic pain model
View evidence from paper
“In the capsaicin mouse model of neuropathic pain”
Test Compound Administration
Administer test compound to evaluate analgesic activity
Note: Compound 1 was tested at 0.25 mg/kg body weight
View evidence from paper
“1 showed 70% analgesic activity at the very low dose of 0.25 mg/kg body weight”
Analgesic Activity Assessment
Measure analgesic activity of test compounds
Note: Compound 1 showed 70% analgesic activity
View evidence from paper
“1 showed 70% analgesic activity at the very low dose of 0.25 mg/kg body weight”