Chronic VEGF-A Inhibition in Normal Adult Animals
Objective: To assess the effects of chronic VEGF-A inhibition on retinal ganglion cell survival and vascular parameters in normal adult animals
This is a Chronic VEGF-A Inhibition in Normal Adult Animals protocol using Not explicitly stated in provided text as the model organism. The procedure involves 3 procedural steps. Extracted from a 2007 paper published in American Journal Of Pathology.
Model and subjects
Not explicitly stated in provided text • Not explicitly stated in provided text • unknown • adult • Not explicitly stated in provided text
Study window
Estimated timing pending
Core workflow
Chronic VEGF-A Inhibition • Assessment of Retinal Ganglion Cell Survival • Assessment of Vascular Parameters
Primary readouts
- Retinal ganglion cell survival/loss
- Vascular parameters
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Chronic VEGF-A Inhibition
Chronic inhibition of VEGF-A function was performed in normal adult animals
Note: This was a long-term inhibition study to assess effects on retinal ganglion cells and vascular parameters
View evidence from paper
“chronic inhibition of VEGF-A function in normal adult animals led to a significant loss of retinal ganglion cells”
Assessment of Retinal Ganglion Cell Survival
Evaluation of retinal ganglion cell survival following chronic VEGF-A inhibition
Note: Chronic VEGF-A inhibition resulted in significant loss of retinal ganglion cells
View evidence from paper
“chronic inhibition of VEGF-A function in normal adult animals led to a significant loss of retinal ganglion cells”
Assessment of Vascular Parameters
Evaluation of vascular parameters in response to chronic VEGF-A inhibition
Note: Chronic VEGF-A inhibition had no observable effect on several vascular parameters
View evidence from paper
“chronic inhibition of VEGF-A function in normal adult animals led to a significant loss of retinal ganglion cells yet had no observable effect on several vascular parameters”