Vascular Endothelial Growth Factor-A Is a Survival Factor for Retinal Neurons and a Critical Neuroprotectant during the Adaptive Response to Ischemic Injury

Kazuaki Nishijima, Yin-Shan Ng, Lichun Zhong, John Bradley, William Schubert et al.

American Journal Of Pathology • 2007

DOI PMC

Chronic VEGF-A Inhibition in Normal Adult Animals

behavioralNot explicitly stated in provided textNot explicitly stated in provided text

Objective: To assess the effects of chronic VEGF-A inhibition on retinal ganglion cell survival and vascular parameters in normal adult animals

Protocol Steps

Chronic VEGF-A Inhibition

Chronic inhibition of VEGF-A function was performed in normal adult animals

Not explicitly statedNot specified

Note: This was a long-term inhibition study to assess effects on retinal ganglion cells and vascular parameters

View evidence from paper

“chronic inhibition of VEGF-A function in normal adult animals led to a significant loss of retinal ganglion cells”

Assessment of Retinal Ganglion Cell Survival

Evaluation of retinal ganglion cell survival following chronic VEGF-A inhibition

Not explicitly statedNot specified

Note: Chronic VEGF-A inhibition resulted in significant loss of retinal ganglion cells

View evidence from paper

“chronic inhibition of VEGF-A function in normal adult animals led to a significant loss of retinal ganglion cells”

Assessment of Vascular Parameters

Evaluation of vascular parameters in response to chronic VEGF-A inhibition

Not explicitly statedNot specified

Note: Chronic VEGF-A inhibition had no observable effect on several vascular parameters

View evidence from paper

“chronic inhibition of VEGF-A function in normal adult animals led to a significant loss of retinal ganglion cells yet had no observable effect on several vascular parameters”