Source Paper
Maternal Care and Hippocampal Plasticity: Evidence for Experience-Dependent Structural Plasticity, Altered Synaptic Functioning, and Differential Responsiveness to Glucocorticoids and Stress
D. L. Champagne, R. C. Bagot, F. van Hasselt, G. Ramakers, M. J. Meaney et al.
Journal of Neuroscience • 2008
Contextual Fear Conditioning
Objective: Hippocampal-dependent behavioral test measuring memory formation and retention in offspring exposed to contextual fear conditioning, examining effects of maternal licking and grooming on cognitive performance
This is a Contextual Fear Conditioning protocol using Not explicitly stated in provided text as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2008 paper published in Journal of Neuroscience.
Model and subjects
Not explicitly stated in provided text • Not explicitly stated in provided text • unknown • Adult offspring • Not explicitly stated in provided text
Study window
Estimated timing pending
Core workflow
Contextual Fear Conditioning Test
Primary readouts
- Memory retention in contextual fear conditioning
- Comparison of memory performance between low LG and high LG offspring
- Enhanced memory in low LG offspring under stress-like conditions
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Contextual Fear Conditioning Test
Adult offspring were tested in a hippocampal-dependent contextual fear-conditioning paradigm to measure memory formation and retention
Note: Test was conducted on adult offspring from mothers with varying frequencies of licking and grooming behavior
View evidence from paper
“Adult low LG offspring displayed enhanced memory relative to high LG offspring when tested in a hippocampal-dependent, contextual fear-conditioning paradigm”