Delayed Nonmatching-to-Sample Task
Objective: Evaluate the effects of basal forebrain cholinergic system lesions on delayed nonmatching-to-sample performance and memory abilities in cynomolgus monkeys
Protocol Steps
Surgical lesion creation
Ibotenic acid injections administered to the medial septum, nucleus of the diagonal band of Broca, and nucleus basalis of Meynert in cynomolgus monkeys
Note: Lesions created in basal forebrain cholinergic system
View evidence from paper
“ibotenic acid injections in the medial septum, nucleus of the diagonal band of Broca, and nucleus basalis of Meynert in cynomolgus monkeys”
Delayed nonmatching-to-sample task
Cognitive task administered to assess memory abilities and accuracy in delayed nonmatching-to-sample performance
Note: Task used to evaluate effects of BFCS lesions on cognitive processes
View evidence from paper
“These lesions did not impair accuracy in delayed nonmatching-to-sample, delayed response, simple or concurrent visual discriminations”
Scopolamine sensitivity assessment
Delayed nonmatching-to-sample task repeated with scopolamine injections to assess cholinergic system compromise
Note: Increased sensitivity to scopolamine indicates compromised central cholinergic system
View evidence from paper
“BFCS lesions increased sensitivity to injections of the cholinergic antagonist scopolamine in a delayed nonmatching-to-sample task”