Experiments/Delayed Nonmatching-to-Sample Task

Source Paper

Basal forebrain lesions in monkeys disrupt attention but not learning and memory [published erratum appears in J Neurosci 1995 Mar;15(3): following table of contents]

ML Voytko, DS Olton, RT Richardson, LK Gorman, JR Tobin et al.

Journal of Neuroscience • 1994

DOI PMC

Delayed Nonmatching-to-Sample Task

behavioralcynomolgus monkey

Objective: Evaluate the effects of basal forebrain cholinergic system lesions on delayed nonmatching-to-sample performance and memory abilities in cynomolgus monkeys

This is a Delayed Nonmatching-to-Sample Task protocol using cynomolgus monkey as the model organism. The procedure involves 3 procedural steps, 2 materials. Extracted from a 1994 paper published in Journal of Neuroscience.

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Replication Essentials

Model and subjects

cynomolgus monkey

Study window

Estimated timing pending

Core workflow

Surgical lesion creation • Delayed nonmatching-to-sample task • Scopolamine sensitivity assessment

Primary readouts

Accuracy in delayed nonmatching-to-sample task
Accuracy in delayed response task
Accuracy in simple visual discriminations
Accuracy in concurrent visual discriminations

Key equipment and reagents

Ibotenic acidScopolamine

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Protocol Steps

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Surgical lesion creation

Ibotenic acid injections administered to the medial septum, nucleus of the diagonal band of Broca, and nucleus basalis of Meynert in cynomolgus monkeys

Note: Lesions created in basal forebrain cholinergic system

View evidence from paper

“ibotenic acid injections in the medial septum, nucleus of the diagonal band of Broca, and nucleus basalis of Meynert in cynomolgus monkeys”