Experiments/Delayed Response Task

Source Paper

Basal forebrain lesions in monkeys disrupt attention but not learning and memory [published erratum appears in J Neurosci 1995 Mar;15(3): following table of contents]

ML Voytko, DS Olton, RT Richardson, LK Gorman, JR Tobin et al.

Journal of Neuroscience • 1994

DOI PMC

Delayed Response Task

behavioralcynomolgus monkey

Objective: Evaluate the effects of basal forebrain cholinergic system lesions on delayed response performance and working memory abilities in primates

This is a Delayed Response Task protocol using cynomolgus monkey as the model organism. The procedure involves 3 procedural steps, 2 materials. Extracted from a 1994 paper published in Journal of Neuroscience.

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Replication Essentials

Model and subjects

cynomolgus monkey

Study window

Estimated timing pending

Core workflow

Surgical lesion creation • Delayed response task administration • Scopolamine sensitivity assessment

Primary readouts

Accuracy in delayed response task
Accuracy in delayed nonmatching-to-sample task
Performance on simple and concurrent visual discriminations
Performance on spatial discriminations

Key equipment and reagents

Ibotenic acidScopolamine

Before You Start

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Protocol Steps

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Surgical lesion creation

Administer ibotenic acid injections into basal forebrain regions including medial septum, nucleus of the diagonal band of Broca, and nucleus basalis of Meynert

Note: Lesions created in cynomolgus monkeys to disrupt basal forebrain cholinergic system

View evidence from paper

“ibotenic acid injections in the medial septum, nucleus of the diagonal band of Broca, and nucleus basalis of Meynert in cynomolgus monkeys”