Source Paper
Information, certainty, and learning
Harris JA, Gallistel CR
eLife • 2026
Magazine Entry Response
Objective: To measure conditioned magazine entry responses during CS presentation and identify when responding first appears
This is a Magazine Entry Response protocol using Rat as the model organism. The procedure involves 5 procedural steps, 4 equipment items, 2 materials. Extracted from a 2026 paper published in eLife.
Model and subjects
Rat • Sprague Dawley • Female • 8-10 weeks • 176
Study window
Estimated timing pending
Core workflow
Skip magazine training • Conduct conditioning sessions • Vary CS-US intervals
Primary readouts
- Magazine entry responses during CS presentation
- Magazine entry responses during ITI periods
- Trial to acquisition using cumulative response rate analysis
- Trial to acquisition using nDKL information-theoretic statistic
Key equipment and reagents
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Protocol Steps
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Skip magazine training
Begin experiment without preliminary magazine training
View evidence from paper
“The rats were not given magazine training”
Conduct conditioning sessions
Run 42 conditioning sessions over 42 consecutive days with CS-US pairings
View evidence from paper
“experiment commenced with the first conditioning session and continued for 42 sessions over 42 consecutive days”
Vary CS-US intervals
Present CS-US intervals that vary according to uniform distribution centered on T value
View evidence from paper
“CS-US interval varied from trial-to-trial according to a uniform distribution centred on the value of T”
Record magazine entries
Record photo-beam interruptions during CS and ITI periods automatically
View evidence from paper
“Photo-beam interruptions by entry into the magazine were recorded during each CS and each ITI”
Monitor ITI responses
Record responses during 10 second period before CS onset
View evidence from paper
“recorded during the 10 s period immediately before CS onset”