Modified Neurological Severity Scores (mNSS)
Objective: Assess neurological functioning across motor, sensory, reflex and balance domains using a composite scoring scale in rodent stroke models
This is a Modified Neurological Severity Scores (mNSS) protocol using mice and rats as the model organism. The procedure involves 5 procedural steps, 1 equipment items. Extracted from a 2010 paper published in Experimental & Translational Stroke Medicine.
Model and subjects
mice and rats • Not specified • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Motor assessment - muscle status and abnormal movement evaluation • Sensory assessment - visual, tactile and proprioceptive testing • Reflex testing - pinna and startle reflexes
Primary readouts
- Motor function (muscle status and abnormal movement)
- Sensory function (visual, tactile, proprioceptive)
- Reflex responses (pinna and startle reflexes)
- Balance function
Key equipment and reagents
Verified items
0
Direct vendor links
0
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
Confirm first
- Verify the animal model, intervention setup, and collection timepoints against the source paper.
- Check that every direct vendor link matches the exact specification your lab plans to run.
Use the page like this
- Work through the protocol steps in order and use the inline vendor chips only when you need to source or verify an item.
- Jump to Experimental Context for readouts, data shape, and analysis flow before planning downstream analysis.
Protocol Steps
Start here. The step list is optimized for running the experiment, with direct vendor links available inline when you need to source a cited item.
Motor assessment - muscle status and abnormal movement evaluation
Evaluate motor function including muscle status and abnormal movement patterns
Note: Component of composite mNSS scoring
View evidence from paper
“The mNSS includes a composite of motor (muscle status and abnormal movement), sensory (visual, tactile and proprioceptive), reflex and balance tests”
Sensory assessment - visual, tactile and proprioceptive testing
Evaluate sensory function across visual, tactile and proprioceptive modalities
Note: Component of composite mNSS scoring
View evidence from paper
“The mNSS includes a composite of motor (muscle status and abnormal movement), sensory (visual, tactile and proprioceptive), reflex and balance tests”
Reflex testing - pinna and startle reflexes
Test pinna reflex and startle reflex responses
Note: One point is deducted for the lack of a tested reflex. Reflexes tested are pinna and startle reflexes, which are unlikely related to damage within the MCA territory
View evidence from paper
“the reflexes tested in the mNSS are the pinna and startle reflexes, which are unlikely related to damage within the MCA territory”
Balance assessment
Evaluate balance function
Note: Component of composite mNSS scoring
View evidence from paper
“The mNSS includes a composite of motor (muscle status and abnormal movement), sensory (visual, tactile and proprioceptive), reflex and balance tests”
Scoring and composite calculation
Calculate overall composite score based on test performance
Note: One point is given for the inability to perform each test. An overall composite score is given to determine impairment
View evidence from paper
“One point is given for the inability to perform each test while one point is deducted for the lack of a tested reflex, and an overall composite score is given to determine impairment”