Source Paper
Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions
E Moser, MB Moser, P Andersen
Journal of Neuroscience • 1993
Morris Water Maze
Objective: To investigate the effects of variously sized and localized hippocampal aspiration lesions on spatial learning ability and memory using a Morris water maze task
This is a Morris Water Maze protocol using Not explicitly stated in provided text as the model organism. The procedure involves 4 procedural steps, 1 equipment items. Extracted from a 1993 paper published in Journal of Neuroscience.
Model and subjects
Not explicitly stated in provided text • Not explicitly stated in provided text • unknown • Not explicitly stated in provided text • Not explicitly stated in provided text
Study window
Estimated timing pending
Core workflow
Lesion Surgery • Lesion Volume Determination • Morris Water Maze Training
Primary readouts
- Final escape latencies
- Acquisition rate
- Precision on probe test without platform
- Correlation between lesion volume and degree of impairment
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Lesion Surgery
Subjects underwent hippocampal aspiration lesions of varying sizes and locations (dorsal or ventral)
Note: Lesions were either dorsal or ventral hippocampal lesions, with varying volumes
View evidence from paper
“compared the effects of variously sized and localized hippocampal aspiration lesions on spatial learning”
Lesion Volume Determination
The volume of all hippocampal lesions was determined and measured
Note: Lesion volume was quantified to correlate with behavioral outcomes
View evidence from paper
“The volume of all hippocampal lesions was determined”
Morris Water Maze Training
Subjects were trained in the Morris water maze to assess spatial learning ability
Note: Training assessed acquisition rate and learning precision
View evidence from paper
“compared the effects of variously sized and localized hippocampal aspiration lesions on spatial learning in a Morris water maze”
Probe Test
A probe test without platform was conducted to assess memory precision and learning
Note: Probe test was sensitive to even smaller dorsal lesions
View evidence from paper
“The acquisition rate and precision on a probe test without platform were sensitive to even smaller dorsal lesions”