Source Paper
Functional assessments in the rodent stroke model
Krystal L Schaar, Miranda M Brenneman, Sean I Savitz
Experimental & Translational Stroke Medicine • 2010
View Abstract
Abstract Stroke is a common cause of permanent disability accompanied by devastating impairments for which there is a pressing need for effective treatment. Motor, sensory and cognitive deficits are common following stroke, yet treatment is limited. Along with histological measures, functional outcome in animal models has provided valuable insight to the biological basis and potential rehabilitation efforts of experimental stroke. Developing and using tests that have the ability to identify behavioral deficits is essential to expanding the development of translational therapies. The present aim of this paper is to review many of the current behavioral tests that assess functional outcome after stoke in rodent models. While there is no perfect test, there are many assessments that are sensitive to detecting the array of impairments, from global to modality specific, after stroke.
Morris Water Maze
Objective: Assesses spatial learning and memory in rodents, commonly used to evaluate cognitive deficits following stroke
This is a Morris Water Maze protocol using Rodent (rat or mouse) as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2010 paper published in Experimental & Translational Stroke Medicine.
Model and subjects
Rodent (rat or mouse) • Not specified • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Task-dependent training and testing
Primary readouts
- Spatial learning performance
- Memory retention
- Task-dependent behavioral measures
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Task-dependent training and testing
Morris Water Maze requires task-dependent training and testing protocols. The specific training duration, number of trials per session, and time to complete the test are dependent upon the particular task design and research objectives.
Note: Training time, number of trials per session, and approximate time to complete test are all dependent upon the specific task parameters chosen by the researcher
View evidence from paper
“Morris Water Maze Dependent upon task Dependent upon task Dependent upon task”