Source Paper
Bilateral Orbital Prefrontal Cortex Lesions in Rhesus Monkeys Disrupt Choices Guided by Both Reward Value and Reward Contingency
Alicia Izquierdo, Robin K. Suda, Elisabeth A. Murray
Journal of Neuroscience • 2004
Object Reversal Learning
Objective: Test whether the orbital prefrontal cortex (PFo) is necessary for guiding behavior based on reward value and reward contingency by comparing object reversal learning performance in monkeys with bilateral PFo lesions versus unoperated controls
This is a Object Reversal Learning protocol using rhesus monkey as the model organism. The procedure involves 3 procedural steps. Extracted from a 2004 paper published in Journal of Neuroscience.
Model and subjects
rhesus monkey • 10
Study window
Estimated timing pending
Core workflow
Object Reversal Learning Task • Assessment Timing - Initial Post-Surgery • Assessment Timing - Delayed Post-Surgery
Primary readouts
- Monkeys' ability to reverse choices of objects when stimulus-reward contingencies change
- Performance comparison between PFo-lesioned monkeys and unoperated controls on reversal learning
- Impairment severity in object reversal learning following bilateral PFo removal
Key equipment and reagents
Verified items
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Direct vendor links
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Protocol Steps
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Object Reversal Learning Task
Monkeys are tested on a standard test of flexible stimulus-reward learning where they must learn to reverse their choices based on changing stimulus-reward contingencies
Note: This is a standard test of flexible stimulus-reward learning assessing the ability to alter choices when reward contingencies change
View evidence from paper
“tested on a standard test of flexible stimulus-reward learning, namely object reversal learning”
Assessment Timing - Initial Post-Surgery
First assessment of object reversal learning performance conducted shortly after bilateral PFo removal surgery
Note: Comparison made between operated monkeys and unoperated controls
View evidence from paper
“one performed shortly after surgery”
Assessment Timing - Delayed Post-Surgery
Second assessment of object reversal learning performance conducted approximately 19 months after bilateral PFo removal surgery
Note: Allows assessment of long-term effects of PFo lesions on reversal learning
View evidence from paper
“the other ≈19 months after surgery”