Source Paper
From Struggling (With) Screening Tests to Mouse Models of Depression‐Relevant Neurobehavioral States
Pryce CR
Curr Protoc • 2026
Pavlovian Aversion Learning-Memory
Objective: To measure increased reactivity to acute threats through Pavlovian aversion learning-memory (PALM) as a neurobehavioral state relevant to depression and stress-related disorders
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Protocol Steps
Setup arena configuration
Place mice in arena with electrifiable floor and central divider allowing transfer between compartments
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“allowing transfer between the left and right compartments”
Administer aversive stimulus
Deliver foot electroshock as the aversive stimulus for Pavlovian conditioning
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“foot e‐shock was now the aversive stimulus”
Enable escape response
Allow compartmental transfer via barrier as the operant escape response
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“with compartmental transfer via a barrier or doorway the operant escape response”
Measure aversion learning-memory
Assess Pavlovian aversion learning-memory through tone-foot shock pairing leading to freezing behavior
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“tone‐foot shock pairing leading to freezing behavior as a paradigm with which to study Pavlovian aversive association learning‐memory”