Source Paper
Bilateral Orbital Prefrontal Cortex Lesions in Rhesus Monkeys Disrupt Choices Guided by Both Reward Value and Reward Contingency
Alicia Izquierdo, Robin K. Suda, Elisabeth A. Murray
Journal of Neuroscience • 2004
Reinforcer Devaluation Task
Objective: Assess monkeys' abilities to alter choices of objects when the value of the underlying food has changed to test whether the orbital prefrontal cortex is necessary for guiding behavior based on expected reward value
This is a Reinforcer Devaluation Task protocol using rhesus monkey as the model organism. The procedure involves 5 procedural steps, 1 materials. Extracted from a 2004 paper published in Journal of Neuroscience.
Model and subjects
rhesus monkey • 10
Study window
Estimated timing pending
Core workflow
Reinforcer Devaluation Task • Object Reversal Learning Task • Object Discrimination Learning
Primary readouts
- Attenuation of reinforcer devaluation effects
- Performance on object reversal learning
- Acquisition of object discrimination learning
- Food preference choices
Key equipment and reagents
Verified items
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Direct vendor links
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Protocol Steps
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Reinforcer Devaluation Task
Monkeys are tested on their ability to alter choices of objects when the value of the underlying food has changed. This task assesses whether monkeys can adjust their behavior based on changes in reward value.
Note: This is the primary experimental task measuring orbital prefrontal cortex function in reward-based decision making
View evidence from paper
“a task that assesses the monkeys' abilities to alter choices of objects when the value of the underlying food has changed”
Object Reversal Learning Task
Standard test of flexible stimulus-reward learning where monkeys must learn to reverse their choices based on changing stimulus-reward associations
Note: Comparison task to assess flexible learning abilities
View evidence from paper
“a standard test of flexible stimulus-reward learning, namely object reversal learning”
Object Discrimination Learning
Monkeys are tested on acquisition of object discrimination learning problems to assess basic learning abilities
Note: Control task to verify basic learning capacity is intact
View evidence from paper
“unimpaired in acquisition of object discrimination learning problems”
Food Preference Test
Monkeys are allowed to choose foods alone among six different foods to assess their ability to assign value to familiar foods
Note: Tests satiety mechanisms and value assignment to foods
View evidence from paper
“responded like controls when allowed to choose foods alone, either on a food preference test among six different foods”
Selective Satiation Test
Monkeys are tested after selective satiation to assess their ability to adjust food preferences based on satiety state
Note: Tests whether satiety mechanisms are intact
View evidence from paper
“or after selective satiation”