Visual Delayed Nonmatching-to-Sample Task
Objective: Assessment of visual recognition memory performance in rhesus monkeys with lesions to perirhinal and entorhinal cortex using a visual delayed nonmatching-to-sample task
This is a Visual Delayed Nonmatching-to-Sample Task protocol using rhesus monkey as the model organism. The procedure involves 4 procedural steps, 1 equipment items. Extracted from a 1993 paper published in Journal of Neuroscience.
Model and subjects
rhesus monkey
Study window
Estimated timing pending
Core workflow
Baseline assessment • Combined rhinal cortex lesion group testing • Perirhinal cortex lesion group testing
Primary readouts
- Visual recognition memory performance on delayed nonmatching-to-sample task
- Severity of impairment relative to control animals
- Comparison of deficits between combined lesions and individual lesion groups
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Baseline assessment
Establish baseline performance on visual delayed nonmatching-to-sample task in unoperated control animals
Note: Control group performance serves as comparison for lesioned animals
View evidence from paper
“Performance on visual delayed nonmatching-to-sample was assessed in rhesus monkeys with combined and separate ablations of the perirhinal and entorhinal cortex, as well as in unoperated controls”
Combined rhinal cortex lesion group testing
Assess visual recognition memory performance in animals with combined ablations of perirhinal and entorhinal cortex
Note: Combined lesions yielded striking impairment on the task
View evidence from paper
“Combined (i.e., rhinal cortex) lesions yielded a striking impairment on this task, one almost as severe as that seen after combined amygdalohippocampal removals”
Perirhinal cortex lesion group testing
Assess visual recognition memory performance in animals with ablations of perirhinal cortex alone
Note: Perirhinal cortex lesions alone produced deficit nearly as severe as combined rhinal cortex lesions
View evidence from paper
“Ablations of the perirhinal cortex alone produced a deficit nearly as severe as that found after rhinal cortex lesions”
Entorhinal cortex lesion group testing
Assess visual recognition memory performance in animals with ablations of entorhinal cortex alone
Note: Entorhinal cortex lesions alone produced only mild deficit
View evidence from paper
“Ablations of the entorhinal cortex alone produced only a mild deficit”