Source Paper
Dissociable Forms of Inhibitory Control within Prefrontal Cortex with an Analog of the Wisconsin Card Sort Test: Restriction to Novel Situations and Independence from “On-Line” Processing
R. Dias, T. W. Robbins, A. C. Roberts
Journal of Neuroscience • 1997
Wisconsin Card Sort Test Analog
Objective: Measure inhibitory control and response set suppression in novel situations using an analog of the Wisconsin Card Sort Test
This is a Wisconsin Card Sort Test Analog protocol using Not explicitly stated in provided text as the model organism. The procedure involves 5 procedural steps. Extracted from a 1997 paper published in Journal of Neuroscience.
Model and subjects
Not explicitly stated in provided text • Not explicitly stated in provided text • unknown • Not explicitly stated in provided text • Not explicitly stated in provided text
Study window
Estimated timing pending
Core workflow
Attentional Set-Shifting Task • Assess Lateral Prefrontal Cortex Function • Assess Orbitofrontal Cortex Function
Primary readouts
- Inhibitory control in attentional selection
- Inhibitory control in affective processing
- Response set suppression in novel situations
- Discrimination reversal performance
Key equipment and reagents
Verified items
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Protocol Steps
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Attentional Set-Shifting Task
Subjects perform attentional set-shifting and discrimination reversal tasks sensitive to prefrontal damage
Note: Task is qualitatively similar to human Wisconsin Card Sort Test procedures
View evidence from paper
“Attentional set-shifting and discrimination reversal are sensitive to prefrontal damage in the marmoset in a manner qualitatively similar to that seen in man”
Assess Lateral Prefrontal Cortex Function
Evaluate inhibitory control in attentional selection through set-shifting performance
Note: Lateral prefrontal cortex is critical locus for shifting attentional set between perceptual dimensions
View evidence from paper
“lateral but not orbital prefrontal cortex is the critical locus in shifting an attentional set between perceptual dimensions”
Assess Orbitofrontal Cortex Function
Evaluate inhibitory control in affective processing through stimulus-reward association reversal
Note: Orbital prefrontal cortex is critical for reversing stimulus-reward associations within a perceptual dimension
View evidence from paper
“orbital but not lateral prefrontal cortex is the critical locus in reversing a stimulus–reward association within a particular perceptual dimension”
Test Novel Situation Performance
Measure inhibitory control impairments specifically in novel situations
Note: Impairments in inhibitory control induced by prefrontal damage are restricted to novel situations
View evidence from paper
“impairments in inhibitory control induced by prefrontal damage are restricted to novel situations”
Assess Response Set Acquisition vs Suppression
Determine whether prefrontal areas involved in suppression of response sets are also involved in acquisition
Note: Prefrontal areas involved in suppression of previously established response sets are not involved in acquisition
View evidence from paper
“those prefrontal areas involved in the suppression of previously established response sets are not involved in the acquisition of such response sets”