Y Maze
Objective: Assessment of hippocampal-dependent spatial learning task to evaluate the impact of hippocampal neurogenesis ablation on spatial cognition
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Equipment2
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Protocol Steps
Hippocampal Neurogenesis Ablation - Method 1
Focal X irradiation of the hippocampus performed on subjects
Note: One of two independent methods used to ablate hippocampal neurogenesis
View evidence from paper
“focal X irradiation of the hippocampus or genetic ablation of glial fibrillary acidic protein-positive neural progenitor cells impaired contextual fear conditioning”
Hippocampal Neurogenesis Ablation - Method 2
Genetic ablation of glial fibrillary acidic protein-positive neural progenitor cells performed on subjects
Note: One of two independent methods used to ablate hippocampal neurogenesis
View evidence from paper
“focal X irradiation of the hippocampus or genetic ablation of glial fibrillary acidic protein-positive neural progenitor cells impaired contextual fear conditioning”
Y Maze Spatial Learning Task
Subjects are tested on the Y maze to assess hippocampal-dependent spatial learning
Note: This task was unaffected by hippocampal neurogenesis ablation
View evidence from paper
“Hippocampal-dependent spatial learning tasks such as the Morris water maze and Y maze were unaffected.”