Aerobic Exercise Intervention
Objective: Examine the effects of aerobic exercise on cognition and biomarkers associated with Alzheimer disease pathology in older adults with mild cognitive impairment, and assess sex as a predictor of response
Protocol Steps
Baseline Assessment
Participants undergo baseline testing including glucometabolic tests, treadmill tests, fat distribution assessment via DXA, blood collection, and cognitive testing
Note: All baseline measurements performed before intervention begins
View evidence from paper
“Before and after the study, glucometabolic and treadmill tests were performed and fat distribution was assessed using dual-energy x-ray absorptiometry”
Randomization
Participants are randomized to either high-intensity aerobic exercise group or stretching control group
View evidence from paper
“Participants were randomized either to a high-intensity aerobic exercise or stretching control group”
Aerobic Exercise Intervention
Aerobic exercise group exercises under supervision of a fitness trainer at 75% to 85% of heart rate reserve
Note: High-intensity aerobic exercise intervention
View evidence from paper
“The aerobic group exercised under the supervision of a fitness trainer at 75% to 85% of heart rate reserve for 45 to 60 min/d, 4 d/wk for 6 months”
Stretching Control Intervention
Control group carries out supervised stretching activities maintaining heart rate at or below 50% of heart rate reserve
Note: Control condition matched for supervision and frequency
View evidence from paper
“The control group carried out supervised stretching activities according to the same schedule but maintained their heart rate at or below 50% of their heart rate reserve”
Month 3 Assessment
Blood collection and cognitive testing performed at 3-month timepoint
View evidence from paper
“At baseline, month 3, and month 6, blood was collected for assay and cognitive tests were administered”
Month 6 Final Assessment
Repeat all baseline measurements including glucometabolic tests, treadmill tests, DXA assessment, blood collection, and cognitive testing
View evidence from paper
“Before and after the study, glucometabolic and treadmill tests were performed and fat distribution was assessed using dual-energy x-ray absorptiometry”