BBB Locomotor Scoring
Objective: Assessment of locomotor recovery using the Basso, Beattie, and Bresnahan (BBB) scoring system following spinal cord injury and Schwann cell transplantation
This is a BBB Locomotor Scoring protocol using rat as the model organism. The procedure involves 2 procedural steps, 2 equipment items. Extracted from a 2014 paper published in Journal of Neuroscience.
Model and subjects
rat • Not specified in provided text • unknown • Not specified in provided text • Not specified in provided text
Study window
Estimated timing pending
Core workflow
BBB Locomotor Scoring Assessment • CatWalk Gait Analysis
Primary readouts
- BBB locomotor score
- CatWalk gait analysis parameters
- Graft volume
- Schwann cell number
Key equipment and reagents
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Protocol Steps
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BBB Locomotor Scoring Assessment
Rats were assessed using the Basso, Beattie, and Bresnahan (BBB) scoring system to evaluate locomotor recovery following spinal cord injury and transplantation
Note: BBB scoring was used as one of the primary outcome measures for locomotor function
View evidence from paper
“examined the effects of these modifications on graft volume, SC number, degradation of chondroitin sulfate proteoglycans (CSPGs), astrogliosis, SC myelination of axons, propriospinal and supraspinal axon numbers, locomotor outcome (BBB scoring, CatWalk gait analysis)”
CatWalk Gait Analysis
Automated gait analysis was performed to assess locomotor function and gait parameters in addition to BBB scoring
Note: CatWalk gait analysis was performed as a complementary measure to BBB scoring
View evidence from paper
“locomotor outcome (BBB scoring, CatWalk gait analysis)”