Source Paper
The Prefrontal Cortex as a Key Target of the Maladaptive Response to Stress
João J. Cerqueira, François Mailliet, Osborne F. X. Almeida, Thérèse M. Jay, Nuno Sousa
Journal of Neuroscience • 2007
Behavioral Flexibility Test
Objective: Evaluation of behavioral flexibility as a measure of prefrontal cortex integrity in rats exposed to chronic stress
This is a Behavioral Flexibility Test protocol using rat as the model organism. The procedure involves 1 procedural steps. Extracted from a 2007 paper published in Journal of Neuroscience.
Model and subjects
rat • not specified • unknown • not specified • not specified
Study window
Estimated timing pending
Core workflow
Behavioral Flexibility Assessment
Primary readouts
- Behavioral flexibility performance
- Working memory function
- PFC-dependent task performance
- Synaptic plasticity in hippocampal-PFC connection
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Behavioral Flexibility Assessment
Evaluation of behavioral flexibility as a measure of prefrontal cortex integrity
Note: Behavioral flexibility is identified as a function that depends on PFC integrity and was severely disrupted by chronic stress
View evidence from paper
“severely disrupts working memory and behavioral flexibility, two functions that depend on PFC integrity”