Behavioral Testing - Functional Recovery
Objective: Assessment of long-term behavioral outcome and functional recovery in rats after cortical ischemia with G-CSF treatment
Protocol Steps
Cortical Ischemia Induction
Rats were subjected to cortical ischemia using one of two different rat models of acute stroke
Note: Two different rat models were used in this study
View evidence from paper
“G-CSF passes the intact blood-brain barrier and reduces infarct volume in 2 different rat models of acute stroke”
G-CSF Treatment Administration
G-CSF was administered to treated animals following cortical ischemia induction
Note: Treatment timing and dosage not specified in provided text
View evidence from paper
“G-CSF markedly improved long-term behavioral outcome after cortical ischemia”
Long-term Behavioral Assessment
Behavioral testing was conducted to assess functional recovery outcomes in treated and control animals
Note: Assessment measured functional recovery related to neural progenitor response
View evidence from paper
“G-CSF markedly improved long-term behavioral outcome after cortical ischemia, while stimulating neural progenitor response in vivo”