Behavioral Testing - Functional Recovery
Objective: Assessment of long-term behavioral outcome and functional recovery in rats after cortical ischemia with G-CSF treatment
This is a Behavioral Testing - Functional Recovery protocol using rat as the model organism. The procedure involves 3 procedural steps. Extracted from a 2005 paper published in Journal of Clinical Investigation.
Model and subjects
rat • Not specified in provided text • unknown • Not specified in provided text • Not specified in provided text
Study window
Estimated timing pending
Core workflow
Cortical Ischemia Induction • G-CSF Treatment Administration • Long-term Behavioral Assessment
Primary readouts
- Long-term behavioral outcome
- Functional recovery after cortical ischemia
- Infarct volume reduction
- Neural progenitor response
Key equipment and reagents
Verified items
0
Direct vendor links
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Protocol Steps
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Cortical Ischemia Induction
Rats were subjected to cortical ischemia using one of two different rat models of acute stroke
Note: Two different rat models were used in this study
View evidence from paper
“G-CSF passes the intact blood-brain barrier and reduces infarct volume in 2 different rat models of acute stroke”
G-CSF Treatment Administration
G-CSF was administered to treated animals following cortical ischemia induction
Note: Treatment timing and dosage not specified in provided text
View evidence from paper
“G-CSF markedly improved long-term behavioral outcome after cortical ischemia”
Long-term Behavioral Assessment
Behavioral testing was conducted to assess functional recovery outcomes in treated and control animals
Note: Assessment measured functional recovery related to neural progenitor response
View evidence from paper
“G-CSF markedly improved long-term behavioral outcome after cortical ischemia, while stimulating neural progenitor response in vivo”