Source Paper
Effects of Aerobic Exercise on Mild Cognitive Impairment
Laura D. Baker, Laura L. Frank, Karen Foster-Schubert, Pattie S. Green, Charles W. Wilkinson et al.
Archives of Neurology •
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Protocol Steps
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Baseline Assessment
At baseline, participants underwent glucometabolic and treadmill tests, fat distribution assessment using dual-energy x-ray absorptiometry, blood collection for assay, and cognitive testing
Note: Baseline measurements established before intervention
View evidence from paper
“Before and after the study, glucometabolic and treadmill tests were performed and fat distribution was assessed using dual-energy x-ray absorptiometry. At baseline, month 3, and month 6, blood was collected for assay and cognitive tests were administered.”
Randomization to Intervention Groups
Participants were randomized either to a high-intensity aerobic exercise group or stretching control group
Note: Six-month randomized controlled clinical trial design
View evidence from paper
“Participants were randomized either to a high-intensity aerobic exercise or stretching control group.”
Aerobic Exercise Intervention
Aerobic group exercised under the supervision of a fitness trainer at 75% to 85% of heart rate reserve
Note: High-intensity aerobic exercise condition
View evidence from paper
“The aerobic group exercised under the supervision of a fitness trainer at 75% to 85% of heart rate reserve for 45 to 60 min/d, 4 d/wk for 6 months.”
Stretching Control Intervention
Control group carried out supervised stretching activities according to the same schedule but maintained their heart rate at or below 50% of their heart rate reserve
Note: Control condition with minimal cardiovascular demand
View evidence from paper
“The control group carried out supervised stretching activities according to the same schedule but maintained their heart rate at or below 50% of their heart rate reserve.”
Month 3 Assessment
At month 3, blood was collected for assay and cognitive tests were administered
Note: Midpoint assessment during intervention
View evidence from paper
“At baseline, month 3, and month 6, blood was collected for assay and cognitive tests were administered.”
Month 6 Assessment
At month 6, blood was collected for assay and cognitive tests were administered
Note: Final assessment at end of intervention
View evidence from paper
“At baseline, month 3, and month 6, blood was collected for assay and cognitive tests were administered.”
Post-Study Assessment
After the 6-month study, glucometabolic and treadmill tests were performed and fat distribution was assessed using dual-energy x-ray absorptiometry
Note: Post-intervention measurements to assess changes from baseline
View evidence from paper
“Before and after the study, glucometabolic and treadmill tests were performed and fat distribution was assessed using dual-energy x-ray absorptiometry.”