Connectivity-Behavior Correlation Analysis
Objective: Investigate functional connectivity between posterior cingulate cortex (PCC) and medial frontal gyrus/ventral anterior cingulate cortex (MFG/vACC) during working memory task and at rest, and correlate connectivity strength with working memory task performance
This is a Connectivity-Behavior Correlation Analysis protocol using human as the model organism. The procedure involves 4 procedural steps, 1 equipment items. Extracted from a 2006 paper published in Journal of Neuroscience.
Model and subjects
human
Study window
Estimated timing pending
Core workflow
Working Memory Task Administration • Resting State fMRI Acquisition • Functional Connectivity Analysis
Primary readouts
- Functional connectivity strength between PCC and MFG/vACC during working memory task
- Functional connectivity strength between PCC and MFG/vACC during rest
- Working memory task performance scores
- Correlation coefficient between connectivity strength and task performance
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Working Memory Task Administration
Subjects performed a working memory task during fMRI scanning to measure task-induced brain activity and connectivity
Note: Task was designed to assess cognitive performance on working memory
View evidence from paper
“This study investigated the functional connectivity between the PCC and MFG/vACC during a working memory task”
Resting State fMRI Acquisition
Subjects underwent fMRI scanning during rest condition to measure baseline functional connectivity between PCC and MFG/vACC
Note: Resting state connectivity was compared with task-based connectivity
View evidence from paper
“and at rest by examining temporal correlations in magnetic resonance signal levels between the regions”
Functional Connectivity Analysis
Examined temporal correlations in magnetic resonance signal levels between PCC and MFG/vACC regions to determine functional connectivity strength in both task and rest conditions
Note: Two regions were assessed for functional connectivity in both conditions
View evidence from paper
“The two regions were functionally connected in both conditions”
Connectivity-Behavior Correlation Analysis
Correlated the strength of functional connection between PCC and MFG/vACC with working memory task performance to assess relationship between brain network coupling and cognitive abilities
Note: Positive correlation was found between connectivity strength and task performance in both task and rest conditions
View evidence from paper
“performance on the working memory task was positively correlated with the strength of this functional connection not only during the working memory task, but also at rest”