Source Paper
Contrasting Roles of Basolateral Amygdala and Orbitofrontal Cortex in Impulsive Choice
Catharine A. Winstanley, David E. H. Theobald, Rudolf N. Cardinal, Trevor W. Robbins
Journal of Neuroscience • 2004
Delay-Discounting Procedure
Objective: To measure impulsive choice and intolerance to delay of reinforcement in rats with excitotoxic lesions of the basolateral amygdala and orbitofrontal cortex using a delay-discounting procedure
This is a Delay-Discounting Procedure protocol using rat as the model organism. The procedure involves 2 procedural steps. Extracted from a 2004 paper published in Journal of Neuroscience.
Model and subjects
rat
Study window
Estimated timing pending
Core workflow
Delay-Discounting Task Testing • Measure Preference for Immediate vs Delayed Rewards
Primary readouts
- Choice of small immediate reward versus larger delayed reward
- Degree of impulsive choice
- Intolerance to delay of reinforcement
- Preference patterns for delayed rewards
Key equipment and reagents
Verified items
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Direct vendor links
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Protocol Steps
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Delay-Discounting Task Testing
Rats with excitotoxic lesions of the BLA and OFC were tested on a delay-discounting procedure to evaluate intolerance to delay of reinforcement and measure impulsive choice
Note: The procedure measures choice between small immediate rewards versus larger but delayed rewards
View evidence from paper
“Rats with excitotoxic lesions of the BLA and OFC were tested on such a delay-discounting procedure”
Measure Preference for Immediate vs Delayed Rewards
Evaluate whether lesioned animals show altered preference patterns - BLA lesions increased choice of small immediate reward indicating greater impulsivity, while OFC lesions increased preference for larger delayed reward
Note: BLA lesions resulted in greater impulsivity; OFC lesions had opposite effect
View evidence from paper
“Although lesions of the BLA increased choice of the small immediate reward, indicating greater impulsivity, OFC lesions had the opposite effect, increasing preference for the larger but delayed reward”