Drug Discrimination Test
Objective: Evaluation of substance abuse-related side effects by assessing whether rats discriminate GLYX-13 from other drugs
Gather these items before starting the experiment. Check off items as you prepare.
Equipment1
Not specified • Not specified • Not specified • Not specified
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Protocol Steps
Drug discrimination test setup
Rats were tested in a drug discrimination paradigm to assess whether they could discriminate GLYX-13 from other drugs
Note: This test was used to evaluate substance abuse-related side effects
View evidence from paper
“antidepressant-like effects without exhibiting substance abuse-related, gating, and sedative side effects of ketamine in the drug discrimination”
Administration of test compounds
GLYX-13 and ketamine were administered to rats during the drug discrimination test
Note: Comparison between GLYX-13 and ketamine was made
View evidence from paper
“GLYX-13, a novel NMDAR glycine-site functional partial agonist, produces an antidepressant-like effect in the Porsolt, novelty induced hypophagia, and learned helplessness tests in rats without exhibiting substance abuse-related”
Behavioral observation and discrimination assessment
Rats were observed to determine if they discriminated GLYX-13 from other drugs based on behavioral responses
Note: Results were compared between GLYX-13 and ketamine to assess for substance abuse-related side effects
View evidence from paper
“drug discrimination, conditioned place preference, pre-pulse inhibition and open-field tests”