Elevated Plus-Maze
Objective: Assessment of anxiety-like behavior through measurement of open-arm activity in the elevated plus-maze following chronic stress
This is a Elevated Plus-Maze protocol using rat as the model organism. The procedure involves 2 procedural steps, 1 equipment items. Extracted from a 2002 paper published in Journal of Neuroscience.
Model and subjects
rat • Not specified • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Chronic Immobilization Stress (CIS) or Chronic Unpredictable Stress (CUS) Application • Elevated Plus-Maze Testing
Primary readouts
- Open-arm activity in the elevated plus-maze
- Anxiety-like behavior
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Chronic Immobilization Stress (CIS) or Chronic Unpredictable Stress (CUS) Application
Rats were subjected to either chronic immobilization stress (CIS) or chronic unpredictable stress (CUS) as part of the experimental design
Note: Two different models of chronic stress were examined in this study
View evidence from paper
“we examined the effects of two different models of chronic stress on hippocampal and amygdaloid neuronal morphology in rats”
Elevated Plus-Maze Testing
Following chronic stress exposure, rats were tested in the elevated plus-maze to assess anxiety-like behavior by measuring open-arm activity
Note: CIS reduced open-arm activity while CUS had minimal effect on this measure
View evidence from paper
“CIS, but not CUS, reduced open-arm activity in the elevated plus-maze”