Source Paper
Reduced fear expression after lesions of the ventral hippocampus
Kirsten G. Kjelstrup, Frode A. Tuvnes, Hill-Aina Steffenach, Robert Murison, Edvard I. Moser et al.
Proceedings of the National Academy of Sciences • 2002
Elevated Plus-Maze
Objective: Assessment of innate fear and anxiety-related behavior by measuring avoidance of open arms in an elevated plus-maze
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Protocol Steps
Elevated plus-maze test
Rats are placed in an elevated plus-maze to assess avoidance of open arms as a measure of innate fear and anxiety-related behavior
Note: Measurement of open arm avoidance indicates fear-related behavior
View evidence from paper
“Rats with selective hippocampal lesions failed to avoid open arms in an elevated plus-maze”
Brightly lit chamber confinement test
Rats are confined to a brightly lit chamber and neuroendocrine stress responses are measured
Note: Lesioned rats showed decreased neuroendocrine stress responses
View evidence from paper
“had decreased neuroendocrine stress responses during confinement to a brightly lit chamber”