Time-Dependent Increases in Brain-Derived Neurotrophic Factor Protein Levels within the Mesolimbic Dopamine System after Withdrawal from Cocaine: Implications for Incubation of Cocaine Craving

Jeffrey W. Grimm, Lin Lu, Teruo Hayashi, Bruce T. Hope, Tsung-Ping Su et al.

Journal of Neuroscience • 2003

DOI PMC

Extinction Testing

behavioralratnot specified

Objective: To assess resistance to extinction by measuring lever presses during a 6-hour period when presses are not reinforced and the cue is absent

This is a Extinction Testing protocol using rat as the model organism. The procedure involves 1 procedural steps, 2 equipment items, 2 materials. Extracted from a 2003 paper published in Journal of Neuroscience.

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Replication Essentials

Model and subjects

rat • not specified • unknown • not specified • not specified

Study window

~6 hours hands-on

Core workflow

Extinction Testing

Primary readouts

Number of lever presses during the 6-hour extinction period
Resistance to extinction (continued responding despite lack of reinforcement)

Key equipment and reagents

Operant chamber with leverTone-light cue apparatus

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Protocol Steps

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