Feeding and Motor Activity Assessment
Objective: Measurement of feeding and motor activity indices to determine specificity of learning effects versus general behavioral changes in appetitive instrumental learning
This is a Feeding and Motor Activity Assessment protocol using rat as the model organism. The procedure involves 3 procedural steps, 2 equipment items, 3 materials. Extracted from a 2000 paper published in Journal of Neuroscience.
Model and subjects
rat • Not specified • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Drug infusion into nucleus accumbens core • Measure instrumental learning acquisition • Measure feeding and motor activity indices
Primary readouts
- Acquisition of instrumental learning (lever pressing for food)
- Feeding behavior indices
- Motor activity indices
Key equipment and reagents
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
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- Verify the animal model, intervention setup, and collection timepoints against the source paper.
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Protocol Steps
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Drug infusion into nucleus accumbens core
Infuse SCH-23390 (0.3 nmol) and AP-5 (0.5 nmol) together into the nucleus accumbens core, or infuse each drug separately as control
Note: Low doses were used; when infused separately, these doses had no effect on behavior
View evidence from paper
“Co-infusion of low doses of the D1 receptor antagonist SCH-23390 (0.3 nmol) and AP-5 (0.5 nmol) into the accumbens core”
Measure instrumental learning acquisition
Assess acquisition of appetitive instrumental learning task through lever pressing for food reward
Note: Combined low doses strongly impaired acquisition whereas separate infusions had no effect
View evidence from paper
“strongly impaired acquisition of instrumental learning (lever pressing for food)”
Measure feeding and motor activity indices
Assess feeding behavior and motor activity to determine specificity of learning effects versus general behavioral changes
Note: Combined low doses had no effect on indices of feeding and motor activity, suggesting specific effect on learning
View evidence from paper
“Infusion of the combined low doses had no effect on indices of feeding and motor activity, suggesting a specific effect on learning”