Source Paper
Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V <sub>1b</sub> receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders
Guy Griebel, Jacques Simiand, Claudine Serradeil-Le Gal, Jean Wagnon, Marc Pascal et al.
Proceedings of the National Academy of Sciences • 2002
Forced Swimming Test
Objective: Measure antidepressant-like effects through behavioral despair in forced swimming, assessing the impact of SSR149415 (vasopressin V1b receptor antagonist) on depression-related behaviors in rodents
This is a Forced Swimming Test protocol using rat as the model organism. The procedure involves 2 procedural steps, 1 equipment items, 2 materials. Extracted from a 2002 paper published in Proceedings of the National Academy of Sciences.
Model and subjects
rat • Not specified • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Drug administration • Forced swimming test
Primary readouts
- Behavioral despair
- Antidepressant-like effects
- Immobility duration or frequency
- Coping behavior
Key equipment and reagents
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Protocol Steps
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Drug administration
Administer SSR149415 to test subjects at specified doses
Note: Doses ranged from 10-30 mg/kg administered orally (p.o.)
View evidence from paper
“SSR149415 (10–30 mg/kg, p.o.) produced antidepressant-like effects in both normal and hypophysectomized rats”
Forced swimming test
Place rats in forced swimming apparatus to measure behavioral despair and antidepressant-like effects
Note: Test conducted in both normal and hypophysectomized rats
View evidence from paper
“In the forced swimming test, SSR149415 (10–30 mg/kg, p.o.) produced antidepressant-like effects in both normal and hypophysectomized rats”