General Practice Based Incidence Study
Objective: To establish the incidence and aetiology of infectious intestinal disease in the community and presenting to general practitioners, with comparison to national laboratory-based surveillance
This is a General Practice Based Incidence Study protocol using human as the model organism. The procedure involves 7 procedural steps, 2 equipment items. Extracted from a 1999 paper published in BMJ.
Model and subjects
human • 459975
Study window
Estimated timing pending
Core workflow
Study Design and Setting Establishment • Community Cohort Selection • Case Identification in Community
Primary readouts
- Incidence of infectious intestinal disease in community (19.4/100 person years)
- Incidence of infectious intestinal disease presenting to general practice (3.3/100 person years)
- Proportion of cases presenting to general practitioner (1 in 6)
- Ratio of community cases to national surveillance reports (136:1)
Key equipment and reagents
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Protocol Steps
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Study Design and Setting Establishment
Established population-based community cohort incidence study across 70 general practices in England
Note: Multi-component study design including community surveillance, general practice-based incidence studies, and case linkage to national laboratory surveillance
View evidence from paper
“Design Population based community cohort incidence study, general practice based incidence studies, and case linkage to national laboratory surveillance. Setting 70 general practices throughout England.”
Community Cohort Selection
Randomly selected 9776 patients from the 459,975 patients served by the 70 general practices for community surveillance
Note: Community surveillance component of the study
View evidence from paper
“Participants 459 975 patients served by the practices. Community surveillance of 9776 randomly selected patients.”
Case Identification in Community
Identified cases of infectious intestinal disease in the community cohort through surveillance
Note: 781 cases were identified in the community cohort
View evidence from paper
“781 cases were identified in the community cohort, giving an incidence of 19.4/100 person years”
General Practice Case Identification
Identified cases of infectious intestinal disease presenting to general practitioners across the 70 practices
Note: 8770 cases presented to general practice
View evidence from paper
“8770 cases presented to general practice (3.3/100 person years (2.94 to 3.75)).”
Laboratory Investigation
Sent stool samples for laboratory investigation and microbiological analysis to identify causative organisms
Note: Samples analyzed for bacterial and viral pathogens including salmonella, campylobacter, rotavirus, and small round structured viruses
View evidence from paper
“6.2 stools sent for laboratory investigation, 23 cases presenting to general practice, and 136 community cases.”
National Surveillance Linkage
Linked identified cases to national laboratory-based surveillance system for comparison of reporting rates
Note: One case was reported to national surveillance for every 1.4 laboratory identifications
View evidence from paper
“One case was reported to national surveillance for every 1.4 laboratory identifications, 6.2 stools sent for laboratory investigation, 23 cases presenting to general practice, and 136 community cases.”
Pathogen-Specific Analysis
Analyzed reporting ratios for different microorganisms to national surveillance
Note: Bacterial pathogens showed lower community-to-surveillance ratios than viral pathogens
View evidence from paper
“The ratio of cases in the community to cases reaching national surveillance was lower for bacterial pathogens (salmonella 3.2:1, campylobacter 7.6:1) than for viruses (rotavirus 35:1, small round structured viruses 1562:1).”