Intracranial Injection - Medial Prefrontal Cortex
behavioralratNot specified
Objective: To assess regional effects of GLYX-13 on antidepressant-like behavior when injected directly into the medial prefrontal cortex
Materials & Equipment Checklist
4 items
Gather these items before starting the experiment. Check off items as you prepare.
Equipment1
Not specified • Not specified • Not specified • Not specified
Materials2
Software1
Not specified • Not specified
As an Amazon Associate, we earn from qualifying purchases. Product links help support this free resource.
Protocol Steps
1
Intracranial injection of GLYX-13 into medial prefrontal cortex
Direct injection of GLYX-13 into the medial prefrontal cortex (MPFC) of rats
Not specifiedNot specified
Note: This injection method differs from systemic administration and produces antidepressant-like effects
View evidence from paper
“GLYX-13, unlike ketamine, produced its antidepressant-like effect when injected directly into the medial prefrontal cortex”
2
Behavioral testing following injection
Assessment of antidepressant-like effects using behavioral tests
Not specifiedNot specified
Note: Tests include Porsolt, novelty induced hypophagia, and learned helplessness tests
View evidence from paper
“produces an antidepressant-like effect in the Porsolt, novelty induced hypophagia, and learned helplessness tests in rats”