Learned Helplessness Test
Objective: Assessment of escape deficits following inescapable stress to evaluate antidepressant-like effects of GLYX-13
This is a Learned Helplessness Test protocol using rat as the model organism. The procedure involves 1 procedural steps. Extracted from a 2012 paper published in Neuropsychopharmacology.
Model and subjects
rat • Not specified • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Learned Helplessness Test
Primary readouts
- Escape deficits following inescapable stress
- Antidepressant-like effects
Key equipment and reagents
Verified items
0
Direct vendor links
0
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
Confirm first
- Verify the animal model, intervention setup, and collection timepoints against the source paper.
- Check that every direct vendor link matches the exact specification your lab plans to run.
Use the page like this
- Work through the protocol steps in order and use the inline vendor chips only when you need to source or verify an item.
- Jump to Experimental Context for readouts, data shape, and analysis flow before planning downstream analysis.
Protocol Steps
Start here. The step list is optimized for running the experiment, with direct vendor links available inline when you need to source a cited item.
Learned Helplessness Test
Rats were tested in the learned helplessness paradigm to assess escape deficits following inescapable stress
Note: This test was used as one of three behavioral tests to evaluate antidepressant-like effects of GLYX-13
View evidence from paper
“GLYX-13, a novel NMDAR glycine-site functional partial agonist, produces an antidepressant-like effect in the Porsolt, novelty induced hypophagia, and learned helplessness tests in rats”