GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects

Jeffrey Burgdorf, Xiao-lei Zhang, Katherine L Nicholson, Robert L Balster, J David Leander et al.

Neuropsychopharmacology • 2012

DOI PMC

Learned Helplessness Test

behavioralratNot specified

Objective: Assessment of escape deficits following inescapable stress to evaluate antidepressant-like effects of GLYX-13

Protocol Steps

Learned Helplessness Test

Rats were tested in the learned helplessness paradigm to assess escape deficits following inescapable stress

Not specifiedNot specified

Note: This test was used as one of three behavioral tests to evaluate antidepressant-like effects of GLYX-13

View evidence from paper

“GLYX-13, a novel NMDAR glycine-site functional partial agonist, produces an antidepressant-like effect in the Porsolt, novelty induced hypophagia, and learned helplessness tests in rats”