Source Paper
Reduction of Adult Hippocampal Neurogenesis Confers Vulnerability in an Animal Model of Cocaine Addiction
Michele A. Noonan, Sarah E. Bulin, Dwain C. Fuller, Amelia J. Eisch
Journal of Neuroscience • 2010
Locomotor Activity Assessment
Objective: Measurement of spontaneous locomotor activity in irradiated and control rats to control for general activity differences and verify that suppression of adult hippocampal neurogenesis does not affect general locomotion
This is a Locomotor Activity Assessment protocol using rat as the model organism. The procedure involves 2 procedural steps, 1 equipment items. Extracted from a 2010 paper published in Journal of Neuroscience.
Model and subjects
rat • Not specified in provided text • unknown • Not specified in provided text • Not specified in provided text
Study window
Estimated timing pending
Core workflow
Cranial irradiation treatment • Locomotor activity assessment
Primary readouts
- Spontaneous locomotor activity levels
- Comparison of activity between irradiated and control rats
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Cranial irradiation treatment
Suppress adult hippocampal neurogenesis via cranial irradiation before drug-taking begins
Note: Performed before cocaine self-administration testing
View evidence from paper
“Suppression of adult hippocampal neurogenesis via cranial irradiation before drug-taking”
Locomotor activity assessment
Measure spontaneous locomotor activity in both irradiated and control rats to verify no general enhancement of locomotion
Note: Used as a control measure to ensure irradiation did not affect general activity levels
View evidence from paper
“locomotor activity were unchanged in irradiated rats”