Mechanical Allodynia Testing
Objective: Assessment of mechanical sensitivity and allodynia in hind paws following spinal cord injury in rats receiving Schwann cell transplants
This is a Mechanical Allodynia Testing protocol using rat as the model organism. The procedure involves 2 procedural steps, 1 equipment items. Extracted from a 2014 paper published in Journal of Neuroscience.
Model and subjects
rat • Not specified • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Mechanical allodynia assessment • Thermal sensitivity assessment
Primary readouts
- Mechanical allodynia in hind paws
- Thermal allodynia in hind paws
- Improvement in mechanical and thermal allodynia following treatment
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Mechanical allodynia assessment
Mechanical sensitivity testing was performed on hind paws to assess allodynia following spinal cord injury and transplantation
Note: Testing was conducted as part of comprehensive sensory function evaluation alongside thermal sensitivity testing
View evidence from paper
“examined the effects of these modifications on graft volume, SC number, degradation of chondroitin sulfate proteoglycans (CSPGs), astrogliosis, SC myelination of axons, propriospinal and supraspinal axon numbers, locomotor outcome (BBB scoring, CatWalk gait analysis), and mechanical and thermal sensitivity on the hind paws”
Thermal sensitivity assessment
Thermal sensitivity testing was performed on hind paws to assess thermal allodynia
Note: Conducted in conjunction with mechanical allodynia testing
View evidence from paper
“mechanical and thermal sensitivity on the hind paws”