Morris Water Maze
Objective: Assess spatial learning and memory performance in rats using the Morris water maze task
This is a Morris Water Maze protocol using rat as the model organism. The procedure involves 2 procedural steps, 1 equipment items, 1 materials. Extracted from a 2010 paper published in Journal of Neuroscience.
Model and subjects
rat • Not specified • unknown • middle-aged • Not specified
Study window
Estimated timing pending
Core workflow
Administer CRF1 antagonist • Conduct Morris water maze testing
Primary readouts
- Memory performance in Morris water maze
- Dendritic arborization patterns
- Long-term potentiation (LTP) at CA1 Schaffer collateral synapses
- Hippocampal CRH expression levels
Key equipment and reagents
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
Confirm first
- Verify the animal model, intervention setup, and collection timepoints against the source paper.
- Check that every direct vendor link matches the exact specification your lab plans to run.
Use the page like this
- Work through the protocol steps in order and use the inline vendor chips only when you need to source or verify an item.
- Jump to Experimental Context for readouts, data shape, and analysis flow before planning downstream analysis.
Protocol Steps
Start here. The step list is optimized for running the experiment, with direct vendor links available inline when you need to source a cited item.
Administer CRF1 antagonist
Administer CRF1 receptor blocker either centrally or peripherally following the early-life stress period
Note: Treatment timing is post-stress period
View evidence from paper
“Central or peripheral administration of a CRF1 blocker following the stress period improved memory performance”
Conduct Morris water maze testing
Test spatial learning and memory performance in the Morris water maze apparatus
Note: Performed on middle-aged rats with early-life stress history
View evidence from paper
“memory performance of CES rats in novel-object recognition tests and in the Morris water maze”