Experiments/Morris Water Maze

Source Paper

Behavioral and Anatomical Correlates of Chronic Episodic Hypoxia during Sleep in the Rat

David Gozal, Jill M. Daniel, Gary P. Dohanich

Journal of Neuroscience • 2001

DOI PMC

Morris Water Maze

behavioralratSprague Dawley

Objective: To assess cognitive spatial learning and memory acquisition in rats exposed to chronic episodic hypoxia by measuring escape latencies and swim path lengths to locate a hidden platform

This is a Morris Water Maze protocol using rat as the model organism. The procedure involves 3 procedural steps, 2 equipment items. Extracted from a 2001 paper published in Journal of Neuroscience.

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Replication Essentials

Model and subjects

rat • Sprague Dawley • male • Not specified • Not specified • Not specified

Study window

~2 week study window | ~24.5 hours hands-on

Core workflow

Chronic episodic hypoxia exposure • Morris water maze training • Recovery period

Primary readouts

Escape latencies to locate hidden platform
Swim path lengths to escape hidden platform
Sleep architecture patterns
Apoptosis in CA1 hippocampal region and cortex

Key equipment and reagents

Morris water maze apparatusEnvironmental chamber

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Protocol Steps

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Chronic episodic hypoxia exposure

Rats in the EHYP group were placed in an environmental chamber where oxygen concentrations were cycled between 10% and 21%

Up to 14 daysNot specified

Note: Cycling occurred either every 90 seconds or every 30 minutes during 12 hours of daylight. For the remaining 12 hours, EHYP rats breathed room air. Control rats spent 14 days in room air.

View evidence from paper

“Exposures consisted of up to14 d in an environmental chamber in which O 2 concentrations were cycled between 10 and 21% every 90 sec or 30 min during 12 hr of daylight. For the remaining 12 hr, EHYP rats breathed room air, while controls spent 14 d in room air”