Experiments/Morris Water Maze

Source Paper

Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, or Strawberry Dietary Supplementation

James A. Joseph, Barbara Shukitt-Hale, Natalia A. Denisova, Donna Bielinski, Antonio Martin et al.

Journal of Neuroscience • 1999

DOI PMC

Morris Water Maze

behavioralratFischer 344

Objective: Assess spatial learning and memory in aged rats using the Morris water maze task to evaluate the effects of dietary antioxidant supplementation on cognitive performance

This is a Morris Water Maze protocol using rat as the model organism. The procedure involves 2 procedural steps, 1 equipment items, 3 materials. Extracted from a 1999 paper published in Journal of Neuroscience.

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Replication Essentials

Model and subjects

rat • Fischer 344 • not specified • 19 months old • not specified • not specified

Study window

~8 week study window

Core workflow

Dietary supplementation period • Morris water maze testing

Primary readouts

Morris water maze performance (spatial learning and memory)
Motor behavioral performance on rod walking task
Motor behavioral performance on accelerod task
Oxotremorine enhancement of K+-evoked dopamine release from striatal slices

Key equipment and reagents

Morris water mazeStrawberry dietary supplement

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Protocol Steps

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Dietary supplementation period

Rats received dietary supplements of strawberry, spinach, or blueberry extracts mixed into their diet

8 weeksnot specified

Note: Supplements administered to 19-month-old Fischer 344 rats at specified concentrations per kilogram of diet

View evidence from paper

“such supplements (strawberry, spinach, or blueberry at 14.8, 9.1, or 18.6 gm of dried aqueous extract per kilogram of diet, respectively) fed for 8 weeks to 19-month-old Fischer 344 rats”