Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients

Mateus M Bergamaschi, Regina Helena Costa Queiroz, Marcos Hortes Nisihara Chagas, Danielle Chaves Gomes de Oliveira, Bruno Spinosa De Martinis et al.

Neuropsychopharmacology • 2011

DOI PMC

Negative Self-Statement Scale

behavioralhuman

Objective: Measure negative self-statements and cognitive responses during a simulated public speaking task in social anxiety disorder patients

Materials & Equipment Checklist

2 items

Gather these items before starting the experiment. Check off items as you prepare.

Materials2

Cannabidiol (CBD)

Amazon

Placebo

Amazon

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Protocol Steps

Subject Allocation and Randomization

24 treatment-naïve SAD patients allocated to receive either CBD or placebo in a double-blind randomized design. 12 healthy controls performed SPST without medication.

Note: Double-blind procedure maintained throughout

View evidence from paper

“24 never-treated patients with SAD were allocated to receive either CBD (600 mg; n=12) or placebo (placebo; n=12) in a double-blind randomized design”

Pre-treatment Administration

CBD or placebo administered to SAD patients prior to simulated public speaking test

1 hour and a half before the test

Note: Timing is critical for drug absorption

View evidence from paper

“CBD (600 mg; n=12) or placebo (placebo; n=12) in a double-blind randomized design 1 h and a half before the test”

Simulated Public Speaking Test (SPST) Performance

Subjects perform the SPST while subjective and physiological measures are collected

Note: Each volunteer participated in only one experimental session

View evidence from paper

“Each volunteer participated in only one experimental session in a double-blind procedure”