Source Paper
Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.
S Rajagopalan, S Kurz, T Münzel, M Tarpey, B A Freeman et al.
Journal of Clinical Investigation • 1996
Norepinephrine Infusion
Objective: To induce hypertension via norepinephrine infusion as a control comparison for angiotensin II-induced hypertension effects on vascular superoxide production
Gather these items before starting the experiment. Check off items as you prepare.
Equipment2
Materials1
Not specified • Not specified • Not specified • Not specified
1 item available from ConductScience
Estimated: $1,490.00
As an Amazon Associate, we earn from qualifying purchases. Product links help support this free resource.
Protocol Steps
Norepinephrine infusion initiation
Administer norepinephrine via systemic infusion at specified dose
Note: Dose of 2.75 mg/kg per day produces hypertension comparable to angiotensin II
View evidence from paper
“NE infusion (2.75 mg/kg per d) produced a similar degree of hypertension”
Blood pressure monitoring
Measure systolic blood pressure to confirm hypertension induction
Note: Used as comparison control for angiotensin II effects
View evidence from paper
“Infusion of angiotensin II (0.7 mg/kg per d) increased systolic blood pressure”