Novel Object Preference Task
Objective: To examine the role of the hippocampus in recognition memory tasks, specifically testing whether the hippocampus is involved in novel object preference tasks that require animals to distinguish novel from familiar objects based on familiarity
This is a Novel Object Preference Task protocol using rat as the model organism. The procedure involves 3 procedural steps, 1 equipment items, 1 materials. Extracted from a 2011 paper published in Journal of Neuroscience.
Model and subjects
rat • Not specified • Not specified • Not specified • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Surgical lesion creation • Novel object preference task • Additional recognition memory tasks
Primary readouts
- Novel object preference performance
- Object-in-place memory performance
- Temporal order memory performance
- Recognition memory judgments based on object familiarity
Key equipment and reagents
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Protocol Steps
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Surgical lesion creation
Bilateral cytotoxic lesions were created in the hippocampus, perirhinal cortex, or prefrontal cortex in different groups of rats
Note: Different experimental groups received lesions in different brain regions
View evidence from paper
“Rats with bilateral cytotoxic lesions in the hippocampus or perirhinal or prefrontal cortex were tested”
Novel object preference task
Animals were tested on a spontaneous object recognition task requiring them to make recognition memory judgments using familiarity, distinguishing novel objects from familiar objects
Note: This task specifically tests object familiarity-based recognition memory
View evidence from paper
“spontaneous object recognition tasks requiring the animals to make recognition memory judgments using familiarity (novel object preference)”
Additional recognition memory tasks
Animals were also tested on object-in-place memory tasks and temporal order memory tasks to examine different types of mnemonic information
Note: Multiple task types were used to test different recognition memory components
View evidence from paper
“tested on a battery of spontaneous object recognition tasks requiring the animals to make recognition memory judgments using familiarity (novel object preference); object–place information (object-in-place memory), or recency information (temporal order memory)”