GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects

Jeffrey Burgdorf, Xiao-lei Zhang, Katherine L Nicholson, Robert L Balster, J David Leander et al.

Neuropsychopharmacology • 2012

DOI PMC

Novelty Induced Hypophagia Test

behavioralratNot specified

Objective: Measurement of suppressed feeding behavior in response to novelty as an indicator of antidepressant-like effects

Protocol Steps

Novelty Induced Hypophagia Test

Conduct the novelty induced hypophagia test as one of the behavioral assays to measure antidepressant-like effects

Not specifiedNot specified

Note: This test measures suppressed feeding behavior in response to novelty exposure. The test is used alongside other behavioral tests including Porsolt test and learned helplessness test.

View evidence from paper

“GLYX-13, a novel NMDAR glycine-site functional partial agonist, produces an antidepressant-like effect in the Porsolt, novelty induced hypophagia, and learned helplessness tests in rats”