Object-in-Place Memory Task
Objective: To examine the role of the hippocampus in recognition memory tasks requiring animals to use different types of mnemonic information, specifically testing object-in-place memory where animals must remember the spatial location of objects
This is a Object-in-Place Memory Task protocol using rat as the model organism. The procedure involves 3 procedural steps, 1 equipment items, 1 materials. Extracted from a 2011 paper published in Journal of Neuroscience.
Model and subjects
rat • Not specified • Not specified • Not specified • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Lesion creation • Object-in-place memory task • Spontaneous object recognition testing
Primary readouts
- Recognition memory performance on object-in-place task
- Object location memory accuracy
- Spatial location recognition of objects
- Comparison of performance between lesioned and control groups
Key equipment and reagents
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Protocol Steps
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Lesion creation
Bilateral cytotoxic lesions were created in the hippocampus, perirhinal cortex, or prefrontal cortex in different groups of rats
Note: Experiment 2 also included unilateral hippocampal lesions combined with contralateral lesions in perirhinal or prefrontal cortex
View evidence from paper
“Rats with bilateral cytotoxic lesions in the hippocampus or perirhinal or prefrontal cortex were tested on a battery of spontaneous object recognition tasks”
Object-in-place memory task
Animals were tested on object-in-place memory task requiring recognition memory judgments using object-place information
Note: This task requires animals to remember the spatial location of objects
View evidence from paper
“object–place information (object-in-place memory), or recency information (temporal order memory)”
Spontaneous object recognition testing
Rats were tested in a series of object recognition memory tasks including novel object preference, object-in-place, and temporal order memory tasks
Note: Testing was conducted as a battery of spontaneous object recognition tasks
View evidence from paper
“tested on a battery of spontaneous object recognition tasks requiring the animals to make recognition memory judgments using familiarity (novel object preference); object–place information (object-in-place memory), or recency information”